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Guideline

WHO guidelines for malaria, 13 August 2025

Year of Publication
2025
Issuing Institution
World Health Organization
Links
WHO IRIS,DOI,WHO IRIS,DOI

Recommendations

52 included recommendations

The co-deployment of insecticide-treated nets (ITNs) and Indoor Residual Spraying (IRS) is not recommended for prevention and control of malaria in children and adults in areas with ongoing malaria transmission. Priority should be given to delivering either ITNs or IRS at optimal coverage and to a high standard, rather than introducing the second intervention as a means to compensate for deficiencies in the implementation of the first intervention.

Status
New

Recommended against

Conditional

Semi-quantitative near-patient tests with fixed standard thresholds for deficient, intermediate and normal glucose-6-phosphate dehydrogenase (G6PD) activity should be used to inform administration of specific treatment regimens. The dose of 1 mg/kg/day primaquine for 7 days or single dose tafenoquine should only be given to those above the threshold that corresponds to >70% of normal G6PD activity; and 0.5 mg/kg/day primaquine for 14 days or 0.5 mg/kg/day primaquine for 7 days can be given to those with a threshold that corresponds to > 30% of normal G6PD activity to prevent relapses of P. vivax and P. ovale.

Status
New

Recommended in favor

Strong

Malaria testing and treatment of organized or identifiable groups arriving or returning from malariaendemic areas (2022) In areas approaching elimination or post-elimination settings preventing re-establishment of transmission, organized or identifiable groups arriving or returning from malaria-endemic areas can be tested and treated soon after entry to reduce importation of malaria. Relatively easy access to these groups within a short time after entry is required for this strategy to be feasible and acceptable. This strategy may be particularly critical to areas in post-elimination that are working to prevent re-establishment of transmission.

Status
Maintained

Recommended in favor

Conditional