Practical info In light of concern about the safety of the previously recommended dose of 0.75 mg/kg bw in individuals with G6PD deficiency, a WHO panel reviewed the safety of primaquine as a P. falciparum gametocytocide and concluded that a single dose of 0.25 mg/kg bw of primaquine base is unlikely to cause serious toxicity, even in people with G6PD deficiency [223]. Thus, where indicated a single dose of 0.25mg/kg bw of primaquine base should be given on the first day of treatment, in addition to an ACT, to all patients with parasitologically confirmed P. falciparum malaria except for pregnant women, infants < 1 months of age and women breastfeeding infants < 1 months of age. Secretion of primaquine in breast milk is negligible [224]. Dosing table based on the most widely currently available tablet strength (7.5mg base) (see Table).