Guideline

Clinical management and infection prevention and control for mpox: living guideline, May 2025

Year of Publication

2025

Issuing Institution

World Health Organization

Links

Recommendations

5 included recommendations

WHO suggests that persons with mild, uncomplicated mpox infection cared for at home are not required to isolate provided their lesions are covered and they wear a wellfitting medical mask when in close proximity with others until all lesions are healed.

Status

New

Recommended against

Conditional

Certainty of evidence

Low

In patients with suspected or confirmed mpox infection, WHO suggests that health and care workers use contact and droplet precautions

Status

New

Recommended in favor

Conditional

Certainty of evidence

Low

WHO recommends rapid initiation of antiretroviral therapy (ART) in people with mpox infection and HIV who are ART naïve or have had a prolonged interruption of ART

Status

Maintained

Recommended in favor

Strong

Certainty of evidence

Moderate

WHO suggests that mothers with mpox continue breastfeeding whilst limiting direct contact with their non-infected infant

Status

New

Recommended in favor

Conditional

Certainty of evidence

Low

WHO suggests that mothers who recover from mpox infection and who had withheld breastfeeding and direct contact, to resume breastfeeding and direct contact with the infant as soon as lesions are healed

Status

New

Recommended in favor

Conditional

Certainty of evidence

Very low