Bibliographic information
Recommendation
An HIV post-exposure prophylaxis regimen with two ARV drugs is effective, but three drugs are preferred
Recommended in favor
Conditional
Certainty of evidence
Low
Notes and Remarks
Recommended drug regimensAdults and adolescents• TDF + 3TC (or FTC) is recommended as the preferred backbone regimen for HIV post-exposure prophylaxis (strong recommendation, low-certainty evidence).• DTG is recommended as the preferred third drug for HIV postexposure prophylaxis (strong recommendation, low-certainty evidence).• When available, ATV/r, DRV/r, LPV/r and RAL may be considered as alternative third drug options for post-exposure prophylaxis(conditional recommendation, low-certainty evidence). Children• ABC + 3TC is recommended as the preferred backbone regimen for HIV PEP for children <30 kg. AZT + 3TC or TDF + 3TC (or FTC) can be considered as alternative regimens (strong recommendation, low-certainty evidence).
- DTG is recommended as the preferred third drug for HIV PEP with approved DTG dosing (strong recommendation, lowcertainty evidence).
- When available, ATV/r, DRV/r, LPV/r and RAL may be considered as alternative third drug options for PEP(conditional recommendation, low-certainty evidence).
Also Featured In
This recommendation also appears in the following guidelines:
Guidelines on post-exposure prophylaxis for HIV and the use of co-trimoxazole prophylaxis for HIV-related infections among adults, adolescents and children: recommendations for a public health approach: December 2014 supplement to the 2013 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection
Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach
Updated recommendations on first-line and second-line antiretroviral regimens and post-exposure prophylaxis and recommendations on early infant diagnosis of HIV
Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: recommendations for a public health approach