Implementation considerations When based in a health facility, daily administration of therapy places a larger burden on TB programmes and patients than does intermittent therapy. Intermittent regimens require stronger programmes with higher-quality patient supervision, but all regimens should be provided with full patient supervision and support. Studies of patients’ preferences for dosing schedules were not systematically reviewed. The higher isoniazid dose used in intermittent therapy was not considered to have an increased incidence of adverse effects. The rifampicin dosage was unchanged when using intermittent therapy. In an international, multicentre, randomized trial (Union Study A), Jindani, Nunn & Enarson found thrice weekly dosing resulted in significantly lower culture conversion rates at 2 months [12]. In developing recommendations, this endpoint was ranked by the GDG as important but not critical for decisionmaking and was not part of the systematic review. For new patients without HIV infection, high- certainty of evidence demonstrated no significant difference between regimens that were administered daily throughout treatment, daily initially and then intermittently in the continuation phase, or thrice weekly throughout treatment. Daily dosing is optimal because it probably achieves better adherence under programme conditions. While the definition of the term varies across countries, “daily” is considered to mean at least five times per week. In addition, meta-analyses showed the superiority of daily (compared with thrice weekly) intensive-phase dosing for patients with pre-treatment isoniazid resistance and for preventing acquired drug resistance in patients overall.