Practical Info The GDG made a conditional recommendation against using remdesivir for treatment of hospitalized patients with COVID-19. If administration of remdesivir is considered, it should be noted that its use is contraindicated in those with liver (ALT > 5 times normal at baseline) or renal (eGFR < 30 mL/minute) dysfunction. To date, it can only be administered intravenously, and it has relatively limited availability.