Bibliographic information
GuidelineWHO recommendations for care of the preterm or low-birth-weight infant.
Year of Publication2022
Issuing InstitutionWorld Health Organization
Recommendation
Updated
When mother’s own milk and donor human milk are not available, nutrient-enriched preterm formula may be considered for very preterm (< 32 weeks’ gestation) or very low-birth-weight (< 1.5 kg) infants.
Recommended in favor
Conditional
Certainty of evidence
Low
Notes and Remarks
Remarks
- The recommendation is conditional on shared decision-making with parents; this includes informing parents about the benefits and risks and the need for further research.
- The GDG was not able to recommend a particular type of preterm formula. Based on most trials included in the evidence review, the GDG suggests that commercially available nutrient-enriched formulas specifically formulated for preterm infants may be considered.
- There was insufficient evidence to make a recommendation for infants who were born at 32–36 weeks’ gestation or with birth weight of 1.5–2.4 kg. For these infants, the GDG considered that standard term formula or nutrient-enriched preterm formula may be considered, depending on clinical judgement.
- The GDG also noted that there was limited information on the timing of initiation and duration of preterm formula in the studies. The GDG suggests initiation and duration should be based on clinical judgement.
- Mothers should also be encouraged and supported before and after birth to provide their own breastmilk (including colostrum) for their infants.