Subgroup considerations The reduced pill burden as a result of using FDCs may be especially valuable in patients with co-morbidities (notably HIV infection) and paediatric patients (who may have some difficulty in swallowing large amounts of medications). Patients with some specific medical conditions (e.g. intolerance to certain TB drugs, liver or renal function impairment) are likely to require individual medication dose adjustment which can be done only with separate drug formulations. Implementation considerations There are no specific implementation considerations as the use of FDC formulations is already widespread.