Practical info In light of concern about the safety of the previously recommended dose of 0.75 mg/kg bw in individuals with G6PD deficiency, a WHO panel reviewed the safety of primaquine as a P. falciparum gametocytocide and concluded that a single dose of 0.25 mg/kg bw of primaquine base is unlikely to cause serious toxicity, even in people with G6PD deficiency [228]. Thus, where indicated a single dose of 0.25mg/kg bw of primaquine base should be given on the first day of treatment, in addition to an ACT, to all patients with parasitologically confirmed P. falciparum malaria except for pregnant women, infants < 1 months of age and women breastfeeding infants < 1 months of age. Secretion of primaquine in breast milk is negligible [229]. Dosing table based on the most widely currently available tablet strength (7.5mg base) Body weight (kg) Single dose of primaquine (mg base) 5 to < 25a 3.75 25 to < 50 7.5 50 to 100 15 a Dosing of young children weighing < 10 kg is limited by the tablet sizes currently available. Please refer to the Policy brief on single-dose primaquine as a gametocytocide in Plasmodium falciparum malaria [230].