Bibliographic information

GuidelineGuidelines for the prevention, diagnosis, care and treatment for people with chronic hepatitis B infection.
Year of Publication2024
Issuing InstitutionWHO

Recommendation

New

Treatment is recommended for all adults with chronic hepatitis B (CHB) (including pregnant women and women of reproductive age) with: HBV DNA >2000 IU/mL and an ALT level above the upper limit of normal (ULN) (30 U/L for men and 19 U/L for women).

Recommended in favor

Strong

Notes and Remarks

Chronic hepatitis B (CHB): Defined as the presence of HBsAg on at least one occasion, and for adolescents and children, persistence of HBsAg for six months or more. The ULN for ALT have been defined as <30 U/L for men and boys and <19 U/L for women and girls for consistency. Some guidelines use different ULN ALT levels for adolescents and children (<22 U/L for girls and <25 U/L for boys). Raised ALT may normalize in pregnancy and is therefore not a good marker for deciding about long-term treatment in pregnancy. Pregnant women should be reassessed after delivery.