Bibliographic information
GuidelineWHO recommendations on adolescent health: guidelines approved by the WHO guidelines review committee
Year of Publication2017
Issuing InstitutionWorld Health Organization
Recommendation
New
Recommended chemotherapy regimens in adults, adolescents and children may include vincristine with bleomycin and doxorubicin (ABV), bleomycin with vincristine (BV), and when available or feasible, liposomal anthracyclines (doxorubicin or daunorubicin), paclitaxel or oral etoposide at sites with the infrastructure, staff and resources to administer chemotherapy drugs and provide appropriate monitoring and supportive care.
Recommended in favor
Conditional
Certainty of evidence
Low
Notes and Remarks
- 1)Chemotherapy can also be considered if KS is progressive despite ART.
- 2)Whenever feasible, suspected KS lesions should be biopsied and diagnosis confirmed, especially before administration of chemotherapy.
- 4)All patients should be monitored for potential development of KS IRIS after ART initiation.
- 5)Chemotherapy drugs, especially those administered during the first trimester of pregnancy, may cause serious adverse fetal effects.