Bibliographic information
GuidelineWHO recommendations on adolescent health: guidelines approved by the WHO guidelines review committee
Year of Publication2017
Issuing InstitutionWorld Health Organization
Recommendation
New
In HIV-infected adults, adolescents and children diagnosed with severe symptomatic Kaposi sarcoma, immediate ART initiation in combination with systemic chemotherapy is recommended.
Recommended in favor
Strong
Certainty of evidence
Low
Notes and Remarks
- 1)Chemotherapy can also be considered if KS is progressive despite ART.
- 2)Whenever feasible, suspected KS lesions should be biopsied and diagnosis confirmed, especially before administration of chemotherapy.
- 4)All patients should be monitored for potential development of KS IRIS after ART initiation.
- 5)Chemotherapy drugs, especially those administered during the first trimester of pregnancy, may cause serious adverse fetal effects.