Updated Recommendation
A new evidence synthesis was published:2022, Guidelines for diagnosing, preventing and managing cryptococcal disease among adults, adolescents and children living with HIV.
View latest version (2022)Bibliographic information
Recommendation
For adults, adolescents and children, a short-course (one-week) induction regimen with amphotericin B deoxycholate (1.0 mg/kg/day) and flucytosine (100 mg/kg/ day, divided into four doses per day), followed by 1 week of fluconazole (1200 mg/day for adults, 12 mg/kg/day for children and adolescents, up to a maximum dose of 800mg daily), is the preferred option for treating cryptococcal meningitis among people living with HIV
Recommended in favor
Strong
Certainty of evidence
Moderate
Notes and Remarks
A minimum package of pre-emptive hydration and electrolyte replacement and toxicity monitoring and management should be provided to minimize treatment toxicity during induction phase with amphotericin B containing regimens and flucytosine.
Also Featured In
This recommendation also appears in the following guidelines:
Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: recommendations for a public health approach
Guidelines for diagnosing, preventing and managing cryptococcal disease among adults, adolescents and children living with HIV.