Updated Recommendation
A new evidence synthesis was published:2025, WHO consolidated guidelines on tuberculosis: module 3: diagnosis
View latest version (2025)Bibliographic information
Recommendation
TB-LAMP may be used as a follow-on test to smear microscopy in adults with signs and symptoms consistent with pulmonary TB, especially when further testing of sputum smear-negative specimens is necessary.
Recommended in favor
Conditional
Certainty of evidence
Very low
Notes and Remarks
- 1.These recommendations apply to settings where conventional sputum-smear microscopycan be performed.WHO consolidated guidelines on tuberculosis: rapid diagnostics for tuberculosis detection. Third edition.682. TB-LAMP should not replace the use of rapid molecular tests that detect TB and resistanceto rifampicin, especially among populations at risk of MDR-TB.3. The test has limited additional diagnostic value over sputum-smear microscopy for testingPLHIV who have signs and symptoms consistent with TB.4. These recommendations apply only to the use of TB-LAMP in testing sputum specimensfrom patients with signs and symptoms consistent with pulmonary TB.5. These recommendations are extrapolated to using TB-LAMP in children, based on thegeneralization of data from adults, while acknowledging the difficulties of collecting sputumspecimens from children.
Also Featured In
This recommendation also appears in the following guidelines:
WHO consolidated guidelines on tuberculosis: module 3: diagnosis – rapid diagnostics for tuberculosis detection: web annex 2. GRADE profiles
WHO consolidated guidelines on tuberculosis: module 3: diagnosis – rapid diagnostics for tuberculosis detection: web annex 2. GRADE profiles
WHO consolidated guidelines on tuberculosis: module 3: diagnosis: rapid diagnostics for tuberculosis detection, 3rd ed.